Publications

   
 

Fan, C.-M. and Maniatis, T. (1989). Two different virus-inducible elements are required for beta-interferon gene regulation. EMBO J. 8, 101-110.


Lenardo, M.J., Fan, C.-M., Maniatis, T. and Baltimore, D. (1989). The involvement of NF-kappa-B in beta-interferon gene regulation reveals its role as widely inducible mediator of signal transduction. Cell 57, 287-294.

Fan, C.-M. and Maniatis, T. (1990). A DNA binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence. Genes & Development 4, 29-42.

Fan, C.-M. and Maniatis, T. (1991). The p50 subunit of NF-kappa-B is generated by processing of p105 through an ATP-dependent pathway. Nature 354, 395-398.

Maniatis, T., Whittemore, L.-A., Du, W., Fan, C.-M., Keller, A., Palombella, V.J. Thanos, D.N. (1992). Positive and Negative Control of Human Interferon-_ Gene Expression. Harvey Lecture 44, 1193-1220. Cold Spring Harbor Press.

Fan, C.-M. and Tessier-Lavigne, M. (1994). Patterning of Mammalian Somites by the Surface Ectoderm and the Notochord: Evidence for Sclerotome Induction by a Hedgehog Homolog. Cell 79, 1175-1186.

Fan, C.-M., Porter, J., Chiang, C., Chang, D.T., Beachy, P.A., and Tessier-Lavigne, M. (1995). Long-Range Sclerotome Induction by Sonic Hedgehog: Direct Role of the Amino-Terminal Cleavage Product and Modulation by the cyclic-AMP Signaling Pathway. Cell 81, 457-465.

Muenke, M., Bone, L., Mitchell, H., Hart, I., Walton, K., Hall-Johnson, K., Ippel. E., Dietz-Band, J., Karloy, K., Fan, C.-M., Tessier-Lavigne, M., and Patterson, D. (1995). Physical Mapping of the Holoprosencephaly Critical Region in 21q22.3, Exclusion of SIM2 as a Candidate Gene for HPE, and Mapping of SIM2 to a Region of Chromosome 21 Important for Down Syndrome. The American Journal of Human Genetics 57, 1074-1079

Pourquie, O., Fan, C.-M., Coltey, M., Hirsinger, E., Watanabe, Y., Breant, C., Francis-West, P., Brickell, P., Tessier-Lavigne, M., and Le Douarin, N.M. (1996). Lateral and Axial Signals involved in Avian Somite Patterning : Role of the BMP4 Protein. Cell 84, 461-471.

Fan, C.-M., Kuwana, E., Bulfone, A., Fletcher, C. F., Copeland, N. G., Jenkins, N. A., Crews, S., Salvador, M., Puelles, L., Rubenstein, J. L. R., and Tessier-Lavigne, M. (1996). Expression Patterns of Two Murine Homologs of Drosophila single-minded Suggest Possible Roles in Embryonic Patterning and in the Pathogenesis of Down Syndrome. Molecular and Cellular Neuroscience 7, 1-16.


Mastick, G.S., Fan, C.-M., Tessier-Lavigne, M., Serbedzija, G.N., MaMahon, A.P., Easter, S.S., Jr. (1996). Early Deletion of Neuromeres in Wnt-1-/- Mutant Mice: Evaluation by Morphological and Molecular Markers. The Journal of Comparative Neurology 374, 246-258.

Probst, M.R., Fan, C.-M.,Tessier-Lavigne, M., and Hankinson, O. (1997). Two Murine Homologs of the Drosophila single-minded Protein that Interact with the Mouse Aryl Hydrocarbon Receptor Nuclear Translocator Protein. Journal of Biological Chemistry 272, 4451-4457.

Michaud, J. and Fan, C.-M. (1997). Single-minded - Two Genes, Three Chromosomes. Genome Research 7, 569-571.

Fan, C.-M., Lee, C.S., and Tessier-Lavigne, M. (1997) A Role for WNT Proteins in Induction of Dermomyotome. Developmental Biology 191, 160-165.

McMahon, J., Takada, S., Zimmerman, L.B., Fan, C.-M., Harland, R.M., and McMahon, A.P. (1998) Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes & Development 12, 1438-1452.

Michaud, J., Rosenquist, T., May, N.R., and C.-M. Fan. (1998). Development of neuroendocrine lineages requires the BHLH-PAS transcription factor SIM1. Genes & Development 12, 3264-3275.

Lee, C.S., Buttitta, L., May, N.R., Kispert, A., and C.-M. Fan. (2000). SHH-N upregulates Sfrp2 in the somitic mesoderm to mediate its competitive action with WNT1 and WNT4. Development 127, 109-118.

Michaud, J.L., De Rossi, C., May, N.R., Holdener, B., and C.-M. Fan. (2000). ARNT2 acts as the dimerization partner of SIM1 for the development of the hypothalamus. Mechanism of Development 90, 253-261.

Epstein, D.J., Martinu, L., Michaud, J.L., Losos, K.M., Fan, C.-M., and A.-L. Joyner. (2000). Members of the bHLH-PAS family regulate Shh transcription in forebrain regions of the mouse CNS.
Development 127, 4701-4709.

Lee, S.C. and C.-M. Fan. (2001). Embryonic expression patterns of the mouse and chick Gas1 genes. Mechanism of Development 101, 293-297.

Lee, C.S., May, N.R., and C.-M. Fan. (2001). Transdifferentiation of the ventral retinal pigmented epithelium to neural retina in the Graowth Arrest Specific Gene 1 mutant. Developmental Biology 236, 17-29.

Liu, Y., May, N.R., C.-M. Fan. (2001). Growth Arrest Specific Gene 1 is a positive growth regulator for the cerebellum. Developmental Biology 236, 30-45.

Lee, C.S., Buttitta, L., and C.-M. Fan. (2001). Evidence that the WNT-inducible growth arrest specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite. Proc. Natl. Acad. Sci. USA 98, 11347-11352.

Michaud, J.L., Boucher, F., Melnyk, A., Gauthier, F, Goshu, E., Levy, E., Mitchell, G.A., Himms-Hagen, J., and C.-M. Fan. (2001). Human Molecular Genetics 10, 1465-1473.

Goshu, E. Jin, H., Fasnacht, R., Spenski, M., Michaud, J.L., and C.-M. Fan. (2002). Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants. Mol.Cell. Biol. 22, 4147-4157.

Liu, Y., Liu, C., Yamada, Y., and C.-M. Fan. (2002). Growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb. Development 129, 5289-5300.

Buttitta, L., Tanaka, T., Chen, A., Ko, M., and C.-M. Fan. (2003) Microarray analysis reveals novel WNT targets in the somites. Developmental Biology 258, 91-104.

Liu C, Goshu E, Wells A, Fan CM. (2003) Identification of the downstream targets of SIM1 and ARNT2, a pair of transcription factors essential for neuroendocrine cell differentiation. J Biol Chem. 278:44857-67.

Buttitta L, Mo R, Hui CC, Fan CM. (2003) Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. Development 130:6233-43.

Goshu E, Jin H, Lovejoy J, Marion JF, Michaud JL, Fan CM. (2004) Sim2 contributes to neuroendocrine hormone gene expression in the anterior hypothalamus. Mol Endocrinol. 18:1251-62. 

Chen AE, Ginty DD, Fan CM. (2005) Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins. Nature 433: 208-9.

Chen AE, Fan CM. (2005) Targeting gene expression in the mouse somite: adenovirus-mediated gene delivery and whole embryo culture. Genesis 42:71-6.